Celiac Peptide Database

Celiac Peptide Database

Consistent with guidance published by European Food Safety Authority (Naegeli et al., 20171), CropLife International members have created the linked document which describes the process used to identify and add new peptides, should they exist, to a list of peptides implicated in celiac disease published by Sollid et al., 20202 and expanded in 2021 by CropLife International members.  Potential peptides were identified through a comprehensive targeted literature search and publication review to determine if the publications contained novel peptides of interest, and if so, whether those peptides conformed to criteria described in Sollid et al., 20123 or were contained in crystal structure data.  Through publication review, it was concluded that no novel peptide sequences beyond those already contained in the 2021 CropLife Celiac Peptide Database were reported.  Consequently, the 2022 CropLife Celiac Peptide database release is identical to the 2021 CropLife Celiac Peptide database but is renamed to reflect the publication review process.

  • A detailed description of the publication search and review process can be found here.
  • The following publications were reviewed.
  • A complete selection of 2022 celiac peptides (updated from the 2021 celiac peptide table as described), including transamidations, can be found here.

Prior versions of the CropLife Celiac Peptide Database and all relevant information are also available:

  • A detailed description of the publication search and review process for the 2021 version can be found here.
  • A list of the publications reviewed in the 2021 version can be found here.
  • A complete selection of 2021 celiac peptides, including transamidations, can be found here.
  • A complete selection of 2020 celiac peptides (from Sollid et al., 2020), including transamidations, can be found here.

[1] https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2017.4862

[2] Sollid, L. M., Tye-Din, J. A., Qiao, S.-W., Anderson, R. P., Gianfrani, C., and Konig, F. (2020). Update 2020: nomenclature and listing of celiac disease relevant gluten epitopes recognized by CD4+ T cells. Immunogenetics 72, 85–88.

[3] Sollid L, Qiao SW, Anderson R, Gianfrani C, Koning F (2012) Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules. Immunogenetics 64: 455–460.


Please Cite This Database As
:
CropLife International Celiac Peptide Database. (2022) https://croplife.org/plant-biotechnology/celiac-peptide-database

 

Disclaimer: The Celiac Peptide Database was created and is updated annually by members of the CropLife International Protein Safety Expert Team. Users acknowledge that CropLife International is not responsible for the accuracy, reliability, and currency of the information and that the information provided may not be one hundred percent (100%) accurate, up-to-date, and free of omissions. CropLife International shall not be held liable for any losses or damages arising from any errors, omissions, or misrepresentations from the use of the information contained in the Celiac Peptide Database.