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["CROPLIFE PRINCIPLES OF REGULATION PROJECT"]
["OPEX (Operator Exposure)  - Tier I risk assessment (version 2.3, 26 October 2018)"]
[]
["Aim of Tool:"]
["This tool aims to assess the risk to operators following the use of plant protection products according to Good Agricultural Practice (GAP). The tool calculates the operator exposure using the US-EPA Occupational Pesticide Handler Exposure Data (PHED + AHETF) augmented by some scenarios for handheld application from the German model, and the risk is expressed as a MoE (Margin of Exposure) and % of dermal + inhalation AOEL for each GAP."]
["PHED = Pesticide Handler Exposure Database; AHETF = Agricultural Handler Exposure Task Force"]
["Protection goal and method:"]
["The protection goal is to ensure no unreasonable adverse effect to the health of operators as a result of exposure to Plant Protection Products (PPP) during their mixing, loading and application under approved use conditions."]
["The exposure is calculated according to exposure surrogate reference tables built from the US EPA and previous German model (Lundehn et al., 1992) datasets. They provide dermal and inhalation exposure values for mixing and loading for different formulation types and for different application techniques. All exposure values are available for different clothing scenarios and PPE (Personal Protective Equipment)."]
["Further information and description of US-EPA Occupational Pesticide Handler Exposure Data are available on the US-EPA web-site.\n"]
["http://www.epa.gov/pesticides/science/handler-exposure-data.html#phed"]
["Occupational Pesticide Handler Exposure Data | Pesticide Science and Assessing Pesticide Risks | US EPA"]
["Handler-exposure-table-2015.pdf"]
[]
[]
["The model calculates the operator exposure in two ways, either using the Margin of Exposure (MoE) - sheet 'Output_OPEX' - or in % of the dermal + inhalation AOEL (Acceptable Operator Exposure Level) - sheet 'Output_OPEX_2'. The 'Output_OPEX_3'  presents the exposure values that are used in the calculation (in mg/kg_bw/d)."]
[]
["Operator exposure using the Margin of Exposure method:"]
["The exposure resulting from the inhalation route (TotalExp_Inh) is calculated as:"]
["TotalExp_Inh = (In_MixLoad_Exp+In_Appl_Exp)*(Appl_rate/1000*Work_rate)/bw"]
[]
["where:","In_MixLoad_Exp = Inhalation Exposure during Mixing and Loading from OPHUE models [mg/kg_ai]"]
[null,"In_App_Exp = Inhalation Exposure during Application from OPHUE models [mg/kg_ai]"]
[null,"Appl_rate = Application rate [g/ha]"]
[null,"Work_rate = hectares treated per day [ha/d], this input is optional only, the model includes default values such as 500 ha/d for aerial application, 80 ha/d for boom application, 15 ha/d for airblast application and 1ha/d for handheld"]
[null,"bw = body weight [kg], 60 kg is assumed by default"]
[]
["The exposure resulting from the dermal exposure route (TotalExp_Der) is calculated as:"]
["TotalExp_Derm = (Der_MixLoad_Exp*DA_undiluted + Der_App_Exp*DA_diluted)*(Appl_rate/1000*Work_rate)/bw"]
[]
["where:","Der_MixLoad_Exp = Dermal Exposure during Mixing and Loading from OPHUE models [mg/kg_ai]"]
[null,"Der_App_Exp = Dermal Exposure during Application from OPHUE models [mg/kg_ai]"]
[null,"Appl_rate = Application rate [g/ha]"]
[null,"Work_rate = hectares treated per day [ha/d], this input is optional only, the model includes default values such as 500 ha/d for aerial application, 80 ha/d for boom application, 15 ha/d for airblast application and 1ha/d for handheld"]
[null,"bw = body weight [kg], 60 kg is assumed by default"]
[null,"DA_undiluted = dermal absorption for undiluted formulation during mixing and loading (% applied dose)"]
[null,"DA_diluted = dermal absorption for diluted formulation during application (% applied dose)"]
[]
["The assumption is that the mixing, loading and application are done by the same person. This is a health-protective assumption. This may not be true in some scenarios (e.g. aerial application). Therefore, for aerial application the exposures for the mixer/loader and the applicator are provided separately (figures in brackets: first figure = mixer/loader, second figure = applicator).  For all other scenarios a separate calculation for a mixer/loader and an applicator need to be conducted outside the tool (see also below under ‘Note’)."]
[]
["The Margin of Exposure is calculated as:"]
["In_MOE = In_NOAEL / TotalExp_Inh"]
["Der_MOE = Der_NOAEL / TotalExp_Derm"]
["Total_MOE = 1/((1/Der_MOE)+(1/In_MOE))"]
[]
["with:","In_MOE or Der_MOE = Inhalation/Dermal Margin of Exposure [-]"]
[null,"In_NOAEL or Der_NOAEL = Inhalation/Dermal No Observed Adverse Effect Level [mg/kg_bw/d]"]
[null,"Total_MOE = total margin of exposure including inhalation and dermal exposure during mixing + loading + application [-]"]
[]
["Operator exposure using the % of the dermal + inhalation AOEL (Acceptable Operator Exposure Level) method:"]
["The systemic exposure resulting from the inhalation route (TotalSysExp_Inh) is calculated as:"]
["TotalSysExp_Inh = (In_MixLoad_Exp+In_Appl_Exp)*(Appl_rate/1000*Work_rate)/bw"]
[]
["where:","In_MixLoad_Exp = Inhalation Exposure during Mixing and Loading from OPHUE models [mg/kg_ai]"]
[null,"In_App_Exp = Inhalation Exposure during Application from OPHUE models [mg/kg_ai]"]
[null,"Appl_rate = Application rate [g/ha]"]
[null,"Work_rate = hectares treated per day [ha/d], this input is optional only, the model includes default values such as 500 ha/d for aerial application, 80 ha/d for boom application, 15 ha/d for airblast application and 1ha/d for handheld"]
[null,"bw = body weight [kg], 60 kg is assumed by default"]
[]
["The systemic exposure resulting from the dermal exposure route (TotalSysExp_Derm) is acalculated as:"]
["TotalSysExp_Derm = (Der_MixLoad_Exp*DA_undiluted + Der_App_Exp*DA_diluted)*(Appl_rate/1000*Work_rate)/bw"]
[]
["where:","Der_MixLoad_Exp = Dermal Exposure during Mixing and Loading from OPHUE models [mg/kg_ai]"]
[null,"Der_App_Exp = Dermal Exposure during Application from OPHUE models [mg/kg_ai]"]
[null,"Appl_rate = Application rate [g/ha]"]
[null,"Work_rate = hectares treated per day [ha/d], this input is optional only, the model includes default values such as 500 ha/d for aerial application, 80 ha/d for boom application, 15 ha/d for airblast application and 1ha/d for handheld"]
[null,"bw = body weight [kg], 60 kg is assumed by default"]
[null,"DA_undiluted = dermal absorption for undiluted formulation during mixing and loading (% applied dose)"]
[null,"DA_diluted = dermal absorption for diluted formulation during application (% applied dose)"]
[]
["The assumption is that the mixing, loading and application are done by the same person. This is a health-protective assumption. This may not be true in some scenarios (e.g. aerial application). Therefore, for aerial application the exposures for the mixer/loader and the applicator are provided separately (figures in brackets: first figure = mixer/loader, second figure = applicator).  For all other scenarios a separate calculation for a mixer/loader and an applicator need to be conducted outside the tool (see also below under ‘Note’)."]
[]
["At Tier-1, the dermal AOEL and inhalation AOEL are calculated from the oral NOAEL, the oral absorption, and using an uncertainty factor of 100. The dermal absorption values for diluted and undiluted formulation are either entered by the user of the tool or set to default values if no values is entered."]
["Der_AOEL = (Or_NOAEL/UF) * (OrAbs/100), if OrAbs <80"]
["Der_AOEL = Or_NOAEL /UF , if OrAbs >=80"]
["Inh_AOEL = (Or_NOAEL/UF) * (OrAbs/100) , if OrAbs <80"]
["Inh_AOEL = Or_NOAEL/UF , if OrAbs >=80"]
[]
["where:","Inh_AOEL or Der_AOEL = Inhalation/Dermal Acceptable Operator Exposure Level [mg/kg_bw/d]"]
[null,"Or_NOAEL = Oral No Observed Adverse Effect Level [mg/kg_bw/d]"]
[null,"OrAbs = Oral absorption [%]"]
[null,"UF = Uncertainty Factor fixed at 100. In cases where the UF needs to be differen than 100, the OAEL and the % AOEL needs to be calculated outside this tool."]
[]
["The exposure in % of the dermal + inhalation AOEL is calculated as:"]
["Exposure [% of dermal + inhalation AOEL] = (TotalSysExp_Der/Der_AOEL)*100 + (TotalSysExp_Inh/Inh_AOEL)*100"]
[]
["At Tier-2, the dermal AOEL and inhalation AOEL are calculated from the dermal NOAEL and the inhalation NOAEL which are provided as inputs. The dermal absorption values for diluted and undiluted formulation are set to 100%."]
["Der_AOEL = Der_NOAEL/UF"]
["Inh_AOEL = Inh_NOAEL/UF"]
[]
["The exposure in % of the dermal + inhalation AOEL is calculated as:"]
["Exposure [% of dermal + inhalation AOEL] = (TotalSysExp_Der/Der_AOEL)*100 + (TotalSysExp_Inh/Inh_AOEL)*100"]
[]
["How to use the tool:"]
["The tool contains a macro, as such the user should allow the macro to run  (\"Enable the content\" when opening the file for the first time) and save the file as an \"Excel Macro Enabled Workbook (*.xlsm)\""]
[]
["The following input values need to be entered in the \"PoR_Inputs\" sheet. The formulation type and Oral NOAEL are two compulsory inputs, without these two inputs, the tool cannot calculate risk for the operator. All other inputs are optional, meaning that if not entered, default values are proposed by the tool."]
["* Formulation name, optional"]
["* Formulation type, compulsory input otherwise the tool will not work, choose between Liquid, Granule or Powder in the  drop-down list appearing when cliking the arrow once cell D6 is selected"]
["* A.I. Name, optional"]
["* A.I. Concentration (%), optional"]
[]
[]
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["* Operator Body Weight (kg), optional input. If left empty the tool assumes 60 kg by default."]
["* Oral NOAEL (mg/kg_bw/d), compulsory input. Need to be entered."]
["* Oral absorption (% applied dose), optional input. If left empty, the tool assumes 100% by default."]
["* Uncertainty factor (-), optional input. If left empty the tool assumes 100 by default."]
["* Dermal absorption - Undiluted (% applied dose), for undiluted formulation during mixing/loading, optional input. If left empty the tool assumes 6% for liquid formulation and 2% for powder, wettable granule and dry granule (Aggarwal et al., 2014)."]
["* Dermal absorption - Diluted (% applied dose) , for diluted formulation during application,  optional input. If left empty, the tool assumes 30% as default (Aggarwal et al., 2014, see below for full reference details)."]
["* Dermal NOAEL (mg/kg_bw/d), optional input. If not available (Tier-1) the tool uses a surrogate calculated from Oral absorption and Oral NOAEL.  When a Dermal NOAEL value is not provided as input, the Dermal exposure is corrected using the Dermal absorption for undiluted and for diluted formulation.When a Dermal NOAEL value is provided, the Dermal exposure is not corrected."]
["* Inhalation NOAEL (mg/kg_bw/d), optional input. If not available (Tier-1) the tool can calculate it from the oral absorption and oral NOAEL, assuming absorption via inhalation is 100%."]
["*By default the tool consider an uncertainty factor of 100 for both dermal and inhalation exposure. If there is a need to use another uncertainty factor, it should be conducted outside the tool."]
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["* Crop Name, optional"]
["* Appl. rate (g_ai/ha/application) = application rate in gram of active ingredient per hectare for each single application, do not enter the total application rate as the model will calculate it. Note it is not possible to enter different application rates for each application."]
["* Application technique, use the list option (click the cell to open the list) and choose the appropriate application technique. If no application technique is specified or wrongly entered (this entry is case sensitive), the model will ask you to enter one."]
["* Work rate (ha/day), hectares treated per day, optional, the model includes default values (500 ha/d for aerial application, 80ha/d for tractor boom application, 15 ha/d for tractor airblast application and 1 ha/d for handheld application)"]
[]
["Click the \"Run OpEx\" box in the PoR_Inputs sheet, the model will run"]
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["Summary of recommended input values"]
["The following values are recommended to be used as input values in the model. "]
[]
[null,"Toxicological endpoints",null,null,"Recommended value",null,null,null,null,"Recommended study (examples)"]
[null,"Oral NOAEL",null,null,"Lowest relevant value from toxicological study with appropriate duration as compared to exposure situation (e.g. short-term/sub-chronic) and for effects considered to be relevant to human risk assessment.",null,null,null,null,"OECD407, OECD408, OECD409, (OECD414, 421, 422, 424)"]
[null,"Oral Absorption",null,null,"Sum of urinary excretion (plus biliary excretion) plus carcass residues from oral absorption/distribution/metabolism/excretion (ADME) studies; alternatively by comparison of excretion after oral and intravenous application.",null,null,null,null,"OECD417"]
[null,"Dermal absorption - undiluted Dermal absorption - diluted",null,null,"In vivo and/or in vitro dermal penetration studies (default values from Aggarwal et al. (2014) are used in absence of data*).",null,null,null,null,"OECD427, OECD428"]
[null,"AOEL",null,null,"NOAEL from appropriate (mostly oral) toxicity study divided by uncertainty factor (standard assumption 100); in case of oral absorption <80%, correction for low oral absorption recommended.",null,null,null,null,"-"]
[null,"Dermal NOAEL",null,null,"NOAEL from appropriate (mostly short-term/subchronic) dermal toxicity study. If dermal toxicty study is not available, the oral subcronic studies could be an option.",null,null,null,null,"OECD410, (OECD411)"]
[null,"Inhalation NOAEL",null,null,"NOAEL from appropriate (mostly short-term/subchronic) inhalation toxicity study. If inhalation toxicity study is not available, the oral subcronic studies could be an option.",null,null,null,null,"OECD412, (OECD413)"]
[]
["Results"]
["For each GAP, the results are displayed as MoE (Total Margin of Exposure) or as % of the AOEL considering:"]
["* long clothes during mixing and loading and long clothes during application"]
["* long clothes + gloves during mixing and loading and long clothes during application"]
["* long clothes + gloves during mixing and loading and long clothes + gloves during application"]
["* double layer of clothes + gloves during mixing and loading and long clothes + gloves during application"]
["* long clothes + gloves + RPE (Respiratory Protective Equipment, protection factor 5) during mixing and loading and long clothes during application"]
["* long clothes + gloves + RPE (Respiratory Protective Equipment, protection factor 5) during mixing and loading and long clothes + gloves during application"]
["* long clothes + gloves + RPE (Respiratory Protective Equipment, protection factor 5) during mixing and loading and long clothes + gloves + RPE 5 during application"]
[]
["A color coding is used which display the results:"]
["* in green when MoE > 100 or %AOEL < 100, generally indicating an acceptable risk"]
["* in red when MoE < 100 or %AOEL >100, generally indicating a risk to operator"]
["Please note that for some active ingredients a different (> or < 100) MoE or Uncertainty factors may be justified depending on the toxicological properties of the compound. It may happen that in some borderline cases, MoE and %AOEL close to 100, the results expressed in MoE and %AOEL generate apparent opposite results due to the different calculation involved."]
[]
["Note:"]
["For aerial application, the results show the Total MoE or % dermal + inhalation AOEL assuming that the same person is mixing/loading and applying the formulation, and in brackets the results are presented considering that 2 different people are mixing/loading the formulation and applying it."]
[]
["Reference:"]
["Aggarwal M, Battalora M, Fisher P, Hüser A, Parr-Dobrzanski R, Soufi M, Mostert V, Strupp C, Whalley P, Wiemann C, Billington R (2014), Assessment of in vitro human dermal absorption studies on pesticides to determine default values, opportunities for read-accross and influence of dilution on absorption, Regul. Toxicol. Pharmacol., 2014 Apr., 68 (3), 412-423"]
[]
["Lundehn J-R, Westphal D, Kieczka H, Krebs B, Löcher-Boltz S, Maasfeld W and Pick ED, 1992. Uniform principles for safeguarding the health of applicators of plant protection products. Mitteilungen aus der Biologischen Bundesanstalt für Land und Forstwirtschaft, Heft 277, Berlin, Germany."]
[]
["The tool was developed by Christine Lorez, Ramanarayanan Tharacad, Wolfgang Maasfeld and Ludovic Loiseau on behalf of the CropLife Operator Exposure group."]
["If you encounter an issue with it, please contact :"]
["ludovic.loiseau@syngenta.com"]

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["CROPLIFE PRINCIPLES OF REGULATION PROJECT"]
["OPEX (Operator Exposure)  - Tier I risk assessment"]
["ludovic.loiseau@syngenta.com"]
[null,"Formulation information"]
[null,"Formulation Name"]
[null,"Formulation Type"]
[null,"A.I. Name"]
[null,"A.I. Concentration (%)"]
[]
[null,"Operator Exposure endpoint",null,null,null,null,null,"Formulation type (drop-down list)"]
[null,"Operator body weight (kg)",null,null,null,null,null,"Liquid"]
[null,"Oral NOAEL (mg/kg_bw/d)",null,null,null,null,null,"Powder"]
[null,"Oral absorption (% applied dose)",null,null,null,null,null,"Wettable granule for spray"]
[null,"Dermal absorption - Undiluted (% applied dose)",null,null,null,null,null,"Dry granule for spreading"]
[null,"Dermal absorption - Diluted (% applied dose)",null,null,null,null,null,"Application technique (drop-down list)"]
[null,null,null,null,null,null,null,"Aerial"]
[null,null,null,null,null,null,null,"Tractor Ground-Boom"]
[null,"Tier-2 Dermal NOAEL (mg/kg_bw/d)",null,null,null,null,null,"Tractor Airblast"]
[null,"Tier-2 Inhalation NOAEL (mg/kg_bw/d)",null,null,null,null,null,"Tractor Dry Granule Spreader"]
[null,null,null,null,null,null,null,"Handheld - backpack"]
[null,null,null,null,null,null,null,"Handheld - handwand"]
[null,null,null,null,null,null,null,"Handheld - dry granule spreading"]
[]
[]
[]
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["Intended use information"]
["Crop name","Appl. rate (g_ai/ha/application)","Application technique","Work rate - optional for OPEX) - (ha/day)",null,null,null,"Default Work Rate"]
[null,null,null,null,null,null,null,"Aerial - 500 ha/day"]
[null,null,null,null,null,null,null,"Tractor Ground-Boom - 80 ha/day"]
[null,null,null,null,null,null,null,"Tractor Airblast - 15 ha/day"]
[null,null,null,null,null,null,null,"Tractor Dry Granule Spreader - 80 ha/day"]
[null,null,null,null,null,null,null,"Handheld (backpack, handwand, granule spreading) - 1 ha/day"]

{"sheet":"Output_OPEX","index":2,"n_rows":6,"n_cols":9,"rows_kept":6,"cut":false,"hidden":false,"merged":[[303,0,303,1],[304,0,304,1],[305,0,305,1],[298,0,298,1],[299,0,299,1],[300,0,300,1],[301,0,301,1],[302,0,302,1],[293,0,293,1],[294,0,294,1],[295,0,295,1],[296,0,296,1],[297,0,297,1],[288,0,288,1],[289,0,289,1],[290,0,290,1],[291,0,291,1],[292,0,292,1],[283,0,283,1],[284,0,284,1],[285,0,285,1],[286,0,286,1],[287,0,287,1],[278,0,278,1],[279,0,279,1],[280,0,280,1],[281,0,281,1],[282,0,282,1],[273,0,273,1],[274,0,274,1],[275,0,275,1],[276,0,276,1],[277,0,277,1],[268,0,268,1],[269,0,269,1],[270,0,270,1],[271,0,271,1],[272,0,272,1],[263,0,263,1],[264,0,264,1],[265,0,265,1],[266,0,266,1],[267,0,267,1],[258,0,258,1],[259,0,259,1],[260,0,260,1],[261,0,261,1],[262,0,262,1],[253,0,253,1],[254,0,254,1],[255,0,255,1],[256,0,256,1],[257,0,257,1],[248,0,248,1],[249,0,249,1],[250,0,250,1],[251,0,251,1],[252,0,252,1],[243,0,243,1],[244,0,244,1],[245,0,245,1],[246,0,246,1],[247,0,247,1],[238,0,238,1],[239,0,239,1],[240,0,240,1],[241,0,241,1],[242,0,242,1],[233,0,233,1],[234,0,234,1],[235,0,235,1],[236,0,236,1],[237,0,237,1],[228,0,228,1],[229,0,229,1],[230,0,230,1],[231,0,231,1],[232,0,232,1],[223,0,223,1],[224,0,224,1],[225,0,225,1],[226,0,226,1],[227,0,227,1],[218,0,218,1],[219,0,219,1],[220,0,220,1],[221,0,221,1],[222,0,222,1],[213,0,213,1],[214,0,214,1],[215,0,215,1],[216,0,216,1],[217,0,217,1],[208,0,208,1],[209,0,209,1],[210,0,210,1],[211,0,211,1],[212,0,212,1],[203,0,203,1],[204,0,204,1],[205,0,205,1],[206,0,206,1],[207,0,207,1],[198,0,198,1],[199,0,199,1],[200,0,200,1],[201,0,201,1],[202,0,202,1],[193,0,193,1],[194,0,194,1],[195,0,195,1],[196,0,196,1],[197,0,197,1],[188,0,188,1],[189,0,189,1],[190,0,190,1],[191,0,191,1],[192,0,192,1],[183,0,183,1],[184,0,184,1],[185,0,185,1],[186,0,186,1],[187,0,187,1],[178,0,178,1],[179,0,179,1],[180,0,180,1],[181,0,181,1],[182,0,182,1],[173,0,173,1],[174,0,174,1],[175,0,175,1],[176,0,176,1],[177,0,177,1],[168,0,168,1],[169,0,169,1],[170,0,170,1],[171,0,171,1],[172,0,172,1],[163,0,163,1],[164,0,164,1],[165,0,165,1],[166,0,166,1],[167,0,167,1],[158,0,158,1],[159,0,159,1],[160,0,160,1],[161,0,161,1],[162,0,162,1],[153,0,153,1],[154,0,154,1],[155,0,155,1],[156,0,156,1],[157,0,157,1],[148,0,148,1],[149,0,149,1],[150,0,150,1],[151,0,151,1],[152,0,152,1],[143,0,143,1],[144,0,144,1],[145,0,145,1],[146,0,146,1],[147,0,147,1],[138,0,138,1],[139,0,139,1],[140,0,140,1],[141,0,141,1],[142,0,142,1],[133,0,133,1],[134,0,134,1],[135,0,135,1],[136,0,136,1],[137,0,137,1],[128,0,128,1],[129,0,129,1],[130,0,130,1],[131,0,131,1],[132,0,132,1],[123,0,123,1],[124,0,124,1],[125,0,125,1],[126,0,126,1],[127,0,127,1],[118,0,118,1],[119,0,119,1],[120,0,120,1],[121,0,121,1],[122,0,122,1],[113,0,113,1],[114,0,114,1],[115,0,115,1],[116,0,116,1],[117,0,117,1],[108,0,108,1],[109,0,109,1],[110,0,110,1],[111,0,111,1],[112,0,112,1],[103,0,103,1],[104,0,104,1],[105,0,105,1],[106,0,106,1],[107,0,107,1],[98,0,98,1],[99,0,99,1],[100,0,100,1],[101,0,101,1],[102,0,102,1],[93,0,93,1],[94,0,94,1],[95,0,95,1],[96,0,96,1],[97,0,97,1],[88,0,88,1],[89,0,89,1],[90,0,90,1],[91,0,91,1],[92,0,92,1],[83,0,83,1],[84,0,84,1],[85,0,85,1],[86,0,86,1],[87,0,87,1],[78,0,78,1],[79,0,79,1],[80,0,80,1],[81,0,81,1],[82,0,82,1],[73,0,73,1],[74,0,74,1],[75,0,75,1],[76,0,76,1],[77,0,77,1],[68,0,68,1],[69,0,69,1],[70,0,70,1],[71,0,71,1],[72,0,72,1],[63,0,63,1],[64,0,64,1],[65,0,65,1],[66,0,66,1],[67,0,67,1],[58,0,58,1],[59,0,59,1],[60,0,60,1],[61,0,61,1],[62,0,62,1],[53,0,53,1],[54,0,54,1],[55,0,55,1],[56,0,56,1],[57,0,57,1],[48,0,48,1],[49,0,49,1],[50,0,50,1],[51,0,51,1],[52,0,52,1],[43,0,43,1],[44,0,44,1],[45,0,45,1],[46,0,46,1],[47,0,47,1],[38,0,38,1],[39,0,39,1],[40,0,40,1],[41,0,41,1],[42,0,42,1],[33,0,33,1],[34,0,34,1],[35,0,35,1],[36,0,36,1],[37,0,37,1],[28,0,28,1],[29,0,29,1],[30,0,30,1],[31,0,31,1],[32,0,32,1],[23,0,23,1],[24,0,24,1],[25,0,25,1],[26,0,26,1],[27,0,27,1],[18,0,18,1],[19,0,19,1],[20,0,20,1],[21,0,21,1],[22,0,22,1],[13,0,13,1],[14,0,14,1],[15,0,15,1],[16,0,16,1],[17,0,17,1],[8,0,8,1],[9,0,9,1],[10,0,10,1],[11,0,11,1],[12,0,12,1],[3,2,3,8],[6,0,6,1],[7,0,7,1],[0,0,0,8],[1,0,1,8]]}
["CROPLIFE PRINCIPLES OF REGULATION PROJECT"]
["Results of the Tier I risk assessment for Operator Exposure"]
[]
[null,null,"Margin of Exposure (MoE)"]
["GAP summary","Mixing/loading","Long clothes","Long clothes + gloves","Long clothes + gloves","Double layer of clothes + gloves","Long clothes + gloves + RPE (5)","Long clothes + gloves + RPE (5)","Long clothes + gloves + RPE (5)"]
[null,"Application","Long clothes","Long clothes","Long clothes + gloves","Long clothes + gloves","Long clothes","Long clothes + gloves","Long clothes + gloves + RPE (5)"]

{"sheet":"Output_OPEX_2","index":3,"n_rows":6,"n_cols":9,"rows_kept":6,"cut":false,"hidden":false,"merged":[[303,0,303,1],[304,0,304,1],[305,0,305,1],[297,0,297,1],[298,0,298,1],[299,0,299,1],[300,0,300,1],[301,0,301,1],[302,0,302,1],[291,0,291,1],[292,0,292,1],[293,0,293,1],[294,0,294,1],[295,0,295,1],[296,0,296,1],[285,0,285,1],[286,0,286,1],[287,0,287,1],[288,0,288,1],[289,0,289,1],[290,0,290,1],[279,0,279,1],[280,0,280,1],[281,0,281,1],[282,0,282,1],[283,0,283,1],[284,0,284,1],[273,0,273,1],[274,0,274,1],[275,0,275,1],[276,0,276,1],[277,0,277,1],[278,0,278,1],[267,0,267,1],[268,0,268,1],[269,0,269,1],[270,0,270,1],[271,0,271,1],[272,0,272,1],[261,0,261,1],[262,0,262,1],[263,0,263,1],[264,0,264,1],[265,0,265,1],[266,0,266,1],[255,0,255,1],[256,0,256,1],[257,0,257,1],[258,0,258,1],[259,0,259,1],[260,0,260,1],[249,0,249,1],[250,0,250,1],[251,0,251,1],[252,0,252,1],[253,0,253,1],[254,0,254,1],[243,0,243,1],[244,0,244,1],[245,0,245,1],[246,0,246,1],[247,0,247,1],[248,0,248,1],[237,0,237,1],[238,0,238,1],[239,0,239,1],[240,0,240,1],[241,0,241,1],[242,0,242,1],[231,0,231,1],[232,0,232,1],[233,0,233,1],[234,0,234,1],[235,0,235,1],[236,0,236,1],[225,0,225,1],[226,0,226,1],[227,0,227,1],[228,0,228,1],[229,0,229,1],[230,0,230,1],[219,0,219,1],[220,0,220,1],[221,0,221,1],[222,0,222,1],[223,0,223,1],[224,0,224,1],[213,0,213,1],[214,0,214,1],[215,0,215,1],[216,0,216,1],[217,0,217,1],[218,0,218,1],[207,0,207,1],[208,0,208,1],[209,0,209,1],[210,0,210,1],[211,0,211,1],[212,0,212,1],[201,0,201,1],[202,0,202,1],[203,0,203,1],[204,0,204,1],[205,0,205,1],[206,0,206,1],[195,0,195,1],[196,0,196,1],[197,0,197,1],[198,0,198,1],[199,0,199,1],[200,0,200,1],[189,0,189,1],[190,0,190,1],[191,0,191,1],[192,0,192,1],[193,0,193,1],[194,0,194,1],[183,0,183,1],[184,0,184,1],[185,0,185,1],[186,0,186,1],[187,0,187,1],[188,0,188,1],[177,0,177,1],[178,0,178,1],[179,0,179,1],[180,0,180,1],[181,0,181,1],[182,0,182,1],[171,0,171,1],[172,0,172,1],[173,0,173,1],[174,0,174,1],[175,0,175,1],[176,0,176,1],[165,0,165,1],[166,0,166,1],[167,0,167,1],[168,0,168,1],[169,0,169,1],[170,0,170,1],[159,0,159,1],[160,0,160,1],[161,0,161,1],[162,0,162,1],[163,0,163,1],[164,0,164,1],[153,0,153,1],[154,0,154,1],[155,0,155,1],[156,0,156,1],[157,0,157,1],[158,0,158,1],[147,0,147,1],[148,0,148,1],[149,0,149,1],[150,0,150,1],[151,0,151,1],[152,0,152,1],[141,0,141,1],[142,0,142,1],[143,0,143,1],[144,0,144,1],[145,0,145,1],[146,0,146,1],[135,0,135,1],[136,0,136,1],[137,0,137,1],[138,0,138,1],[139,0,139,1],[140,0,140,1],[129,0,129,1],[130,0,130,1],[131,0,131,1],[132,0,132,1],[133,0,133,1],[134,0,134,1],[123,0,123,1],[124,0,124,1],[125,0,125,1],[126,0,126,1],[127,0,127,1],[128,0,128,1],[117,0,117,1],[118,0,118,1],[119,0,119,1],[120,0,120,1],[121,0,121,1],[122,0,122,1],[111,0,111,1],[112,0,112,1],[113,0,113,1],[114,0,114,1],[115,0,115,1],[116,0,116,1],[105,0,105,1],[106,0,106,1],[107,0,107,1],[108,0,108,1],[109,0,109,1],[110,0,110,1],[99,0,99,1],[100,0,100,1],[101,0,101,1],[102,0,102,1],[103,0,103,1],[104,0,104,1],[93,0,93,1],[94,0,94,1],[95,0,95,1],[96,0,96,1],[97,0,97,1],[98,0,98,1],[87,0,87,1],[88,0,88,1],[89,0,89,1],[90,0,90,1],[91,0,91,1],[92,0,92,1],[81,0,81,1],[82,0,82,1],[83,0,83,1],[84,0,84,1],[85,0,85,1],[86,0,86,1],[75,0,75,1],[76,0,76,1],[77,0,77,1],[78,0,78,1],[79,0,79,1],[80,0,80,1],[69,0,69,1],[70,0,70,1],[71,0,71,1],[72,0,72,1],[73,0,73,1],[74,0,74,1],[63,0,63,1],[64,0,64,1],[65,0,65,1],[66,0,66,1],[67,0,67,1],[68,0,68,1],[57,0,57,1],[58,0,58,1],[59,0,59,1],[60,0,60,1],[61,0,61,1],[62,0,62,1],[51,0,51,1],[52,0,52,1],[53,0,53,1],[54,0,54,1],[55,0,55,1],[56,0,56,1],[45,0,45,1],[46,0,46,1],[47,0,47,1],[48,0,48,1],[49,0,49,1],[50,0,50,1],[39,0,39,1],[40,0,40,1],[41,0,41,1],[42,0,42,1],[43,0,43,1],[44,0,44,1],[33,0,33,1],[34,0,34,1],[35,0,35,1],[36,0,36,1],[37,0,37,1],[38,0,38,1],[27,0,27,1],[28,0,28,1],[29,0,29,1],[30,0,30,1],[31,0,31,1],[32,0,32,1],[21,0,21,1],[22,0,22,1],[23,0,23,1],[24,0,24,1],[25,0,25,1],[26,0,26,1],[18,0,18,1],[19,0,19,1],[20,0,20,1],[9,0,9,1],[10,0,10,1],[11,0,11,1],[12,0,12,1],[13,0,13,1],[14,0,14,1],[3,2,3,8],[6,0,6,1],[7,0,7,1],[8,0,8,1],[15,0,15,1],[16,0,16,1],[17,0,17,1],[0,0,0,8],[1,0,1,8]]}
["CROPLIFE PRINCIPLES OF REGULATION PROJECT"]
["Results of the Tier I risk assessment for Operator Exposure"]
[]
[null,null,"% of Dermal + Inhalation AOEL"]
["GAP summary","Mixing/loading","Long clothes","Long clothes + gloves","Long clothes + gloves","Double layer of clothes + gloves","Long clothes + gloves + RPE (5)","Long clothes + gloves + RPE (5)","Long clothes + gloves + RPE (5)"]
[null,"Application","Liquid","Long clothes","Long clothes + gloves","Long clothes + gloves","Long clothes","Long clothes + gloves","Long clothes + gloves + RPE (5)"]

{"sheet":"Output_OPEX_3","index":4,"n_rows":6,"n_cols":9,"rows_kept":6,"cut":false,"hidden":false,"merged":[[303,0,303,1],[304,0,304,1],[305,0,305,1],[297,0,297,1],[298,0,298,1],[299,0,299,1],[300,0,300,1],[301,0,301,1],[302,0,302,1],[291,0,291,1],[292,0,292,1],[293,0,293,1],[294,0,294,1],[295,0,295,1],[296,0,296,1],[285,0,285,1],[286,0,286,1],[287,0,287,1],[288,0,288,1],[289,0,289,1],[290,0,290,1],[279,0,279,1],[280,0,280,1],[281,0,281,1],[282,0,282,1],[283,0,283,1],[284,0,284,1],[273,0,273,1],[274,0,274,1],[275,0,275,1],[276,0,276,1],[277,0,277,1],[278,0,278,1],[267,0,267,1],[268,0,268,1],[269,0,269,1],[270,0,270,1],[271,0,271,1],[272,0,272,1],[261,0,261,1],[262,0,262,1],[263,0,263,1],[264,0,264,1],[265,0,265,1],[266,0,266,1],[255,0,255,1],[256,0,256,1],[257,0,257,1],[258,0,258,1],[259,0,259,1],[260,0,260,1],[249,0,249,1],[250,0,250,1],[251,0,251,1],[252,0,252,1],[253,0,253,1],[254,0,254,1],[243,0,243,1],[244,0,244,1],[245,0,245,1],[246,0,246,1],[247,0,247,1],[248,0,248,1],[237,0,237,1],[238,0,238,1],[239,0,239,1],[240,0,240,1],[241,0,241,1],[242,0,242,1],[231,0,231,1],[232,0,232,1],[233,0,233,1],[234,0,234,1],[235,0,235,1],[236,0,236,1],[225,0,225,1],[226,0,226,1],[227,0,227,1],[228,0,228,1],[229,0,229,1],[230,0,230,1],[219,0,219,1],[220,0,220,1],[221,0,221,1],[222,0,222,1],[223,0,223,1],[224,0,224,1],[213,0,213,1],[214,0,214,1],[215,0,215,1],[216,0,216,1],[217,0,217,1],[218,0,218,1],[207,0,207,1],[208,0,208,1],[209,0,209,1],[210,0,210,1],[211,0,211,1],[212,0,212,1],[201,0,201,1],[202,0,202,1],[203,0,203,1],[204,0,204,1],[205,0,205,1],[206,0,206,1],[195,0,195,1],[196,0,196,1],[197,0,197,1],[198,0,198,1],[199,0,199,1],[200,0,200,1],[189,0,189,1],[190,0,190,1],[191,0,191,1],[192,0,192,1],[193,0,193,1],[194,0,194,1],[183,0,183,1],[184,0,184,1],[185,0,185,1],[186,0,186,1],[187,0,187,1],[188,0,188,1],[177,0,177,1],[178,0,178,1],[179,0,179,1],[180,0,180,1],[181,0,181,1],[182,0,182,1],[171,0,171,1],[172,0,172,1],[173,0,173,1],[174,0,174,1],[175,0,175,1],[176,0,176,1],[165,0,165,1],[166,0,166,1],[167,0,167,1],[168,0,168,1],[169,0,169,1],[170,0,170,1],[159,0,159,1],[160,0,160,1],[161,0,161,1],[162,0,162,1],[163,0,163,1],[164,0,164,1],[153,0,153,1],[154,0,154,1],[155,0,155,1],[156,0,156,1],[157,0,157,1],[158,0,158,1],[147,0,147,1],[148,0,148,1],[149,0,149,1],[150,0,150,1],[151,0,151,1],[152,0,152,1],[141,0,141,1],[142,0,142,1],[143,0,143,1],[144,0,144,1],[145,0,145,1],[146,0,146,1],[135,0,135,1],[136,0,136,1],[137,0,137,1],[138,0,138,1],[139,0,139,1],[140,0,140,1],[129,0,129,1],[130,0,130,1],[131,0,131,1],[132,0,132,1],[133,0,133,1],[134,0,134,1],[123,0,123,1],[124,0,124,1],[125,0,125,1],[126,0,126,1],[127,0,127,1],[128,0,128,1],[117,0,117,1],[118,0,118,1],[119,0,119,1],[120,0,120,1],[121,0,121,1],[122,0,122,1],[111,0,111,1],[112,0,112,1],[113,0,113,1],[114,0,114,1],[115,0,115,1],[116,0,116,1],[105,0,105,1],[106,0,106,1],[107,0,107,1],[108,0,108,1],[109,0,109,1],[110,0,110,1],[99,0,99,1],[100,0,100,1],[101,0,101,1],[102,0,102,1],[103,0,103,1],[104,0,104,1],[93,0,93,1],[94,0,94,1],[95,0,95,1],[96,0,96,1],[97,0,97,1],[98,0,98,1],[87,0,87,1],[88,0,88,1],[89,0,89,1],[90,0,90,1],[91,0,91,1],[92,0,92,1],[81,0,81,1],[82,0,82,1],[83,0,83,1],[84,0,84,1],[85,0,85,1],[86,0,86,1],[75,0,75,1],[76,0,76,1],[77,0,77,1],[78,0,78,1],[79,0,79,1],[80,0,80,1],[69,0,69,1],[70,0,70,1],[71,0,71,1],[72,0,72,1],[73,0,73,1],[74,0,74,1],[63,0,63,1],[64,0,64,1],[65,0,65,1],[66,0,66,1],[67,0,67,1],[68,0,68,1],[57,0,57,1],[58,0,58,1],[59,0,59,1],[60,0,60,1],[61,0,61,1],[62,0,62,1],[51,0,51,1],[52,0,52,1],[53,0,53,1],[54,0,54,1],[55,0,55,1],[56,0,56,1],[45,0,45,1],[46,0,46,1],[47,0,47,1],[48,0,48,1],[49,0,49,1],[50,0,50,1],[39,0,39,1],[40,0,40,1],[41,0,41,1],[42,0,42,1],[43,0,43,1],[44,0,44,1],[33,0,33,1],[34,0,34,1],[35,0,35,1],[36,0,36,1],[37,0,37,1],[38,0,38,1],[27,0,27,1],[28,0,28,1],[29,0,29,1],[30,0,30,1],[31,0,31,1],[32,0,32,1],[21,0,21,1],[22,0,22,1],[23,0,23,1],[24,0,24,1],[25,0,25,1],[26,0,26,1],[18,0,18,1],[19,0,19,1],[20,0,20,1],[9,0,9,1],[10,0,10,1],[11,0,11,1],[12,0,12,1],[13,0,13,1],[14,0,14,1],[0,0,0,8],[1,0,1,8],[3,2,3,8],[6,0,6,1],[7,0,7,1],[8,0,8,1],[15,0,15,1],[16,0,16,1],[17,0,17,1]]}
["CROPLIFE PRINCIPLES OF REGULATION PROJECT"]
["Results of the Tier I risk assessment for Operator Exposure"]
[]
[null,null,"Dermal exposure value (D) and Inhalation exposure value (I) (in mg/kg_bw/d)"]
["GAP summary","Mixing/loading","Long clothes","Long clothes + gloves","Long clothes + gloves","Double layer of clothes + gloves","Long clothes + gloves + RPE (5)","Long clothes + gloves + RPE (5)","Long clothes + gloves + RPE (5)"]
[null,"Application","Long clothes","Long clothes","Long clothes + gloves","Long clothes + gloves","Long clothes","Long clothes + gloves","Long clothes + gloves + RPE (5)"]

{"sheet":"OPHUE_models","index":5,"n_rows":91,"n_cols":17,"rows_kept":91,"cut":false,"hidden":false,"merged":[[52,8,52,9],[52,11,52,14],[52,15,52,16],[52,4,52,7],[51,4,51,9],[51,11,51,16]]}
[]
[]
["Formulation type (drop-down list)"]
["Liquid"]
["Powder"]
["Wetable granule for spray"]
["Dry granule for spreading"]
["Application technique (drop-down list)"]
["Aerial"]
["Tractor Ground-Boom"]
["Tractor Airblast"]
["Tractor Dry Granule Spreader"]
["Handheld - backpack"]
["Handheld - handwand"]
["Handheld - granule spreading"]
[]
[]
["SCENARIOS TABLE"]
["Formulation type","Application technique","Scenario name","PoR Scenario number for mixing and loading (see exposure data table below)","PoR Scenario number for Application (see exposure data table below)"]
["Liquid","Aerial","AHETF OPML + CCA",3,5]
[null,"Tractor Ground-Boom","AHETF OPML + OCGB",3,7]
[null,"Tractor Airblast","AHETF OPML + OCAB",3,6]
[null,"Handheld - backpack","AHETF",0,11]
[null,"Handheld - handwand","PHED 35",0,12]
[]
[]
[]
["Powder","Aerial","PHED 4 + AHETF CCA",4,5]
[null,"Tractor Ground-Boom","PHED 4 + AHETF OCGB",4,7]
[null,"Tractor Airblast","PHED 4 + AHETF OCAB",4,6]
[null,"Handheld - backpack","German model",13,14]
[]
[]
[]
[]
["Wettable granule for spray","Aerial","AHETF DFML + CCA",1,5]
[null,"Tractor Ground-Boom","AHETF DFML + OCGB",1,7]
[null,"Tractor Airblast","AHETF DFML + OCAB",1,6]
[null,"Handheld - backpack","AHETF",0,11]
[null,"Handheld - handwand","PHED 35",0,12]
[]
[]
[]
["Dry granule for spreading","Tractor Dry Granule Spreader","PHED 2 + 15",2,8]
[null,"Handheld - granule spreading","PHED 17",0,9]
[]
[]
[]
[]
[]
["EXPOSURE DATA FOR FIELD APPLICATION"]
[null,null,null,null,"recalculated values in mg/kg ai",null,null,null,null,null,null,"original values from US-EPA in mg/lb ai"]
[null,null,null,null,"dermal exposure",null,null,null,"inhalation exposure",null,null,"dermal exposure",null,null,null,"inhalation exposure"]
["PoR Tool Scenario Number","(Name) - Description - Source (OPHUE = Occupational Pesticide Handler Unit Exposure Surrogate Reference Table from US-EPA, September 2015)","Mixing / Loading","Application","long clothes","long clothes; gloves for m/l","long clothes + gloves for m/l + appl","double layer of clothes + gloves for m/l; long clothes + gloves for appl","no protection","RPE (factor 5)",null," long clothes","long clothes; gloves for m/l","long clothes + gloves for m/l + appl","double layer of clothes + gloves for m/l; long clothes + gloves for appl",null,"RPE (factor 5)"]
[null,null,null,null,"PPE0De","PPE1De","PPE2De","PPE3De","PPE0In","PPE1In",null,null,null,null,null,"no protection","dust mask"]
[1,"(AHETF DFML, ex PHED 1) - Mixing/Loading Dry Flowable, wettable granule products - OPHUE","ü",null,{"$f":"L56/B91","v":0.50044933515967205},{"$f":"M56/B91","v":0.11375852728739683},{"$f":"N56/B91","v":0.11375852728739683},{"$f":"O56/B91","v":9.0830452020169566E-2},{"$f":"P56/B91","v":1.9753418691765029E-2},{"$f":"I56/5","v":3.9506837383530054E-3},null,0.22700000000000001,5.16E-2,5.16E-2,4.1200000000000001E-2,8.9599999999999992E-3,{"$f":"P56/5","v":1.7919999999999998E-3}]
[2,"(PHED 2) - Mixing/Loading Granules, granule products for dry spreading - OPHUE","ü",null,{"$f":"L57/B91","v":1.8452691344874254E-2},{"$f":"M57/B91","v":1.5156780525210333E-2},{"$f":"N57/B91","v":1.5156780525210333E-2},{"$f":"O57/B91","v":7.4626475749581056E-3},{"$f":"P57/B91","v":3.7478584571429183E-3},7.4957169142858364E-4,null,8.3700000000000007E-3,6.875E-3,6.875E-3,3.385E-3,1.6999999999999999E-3,3.3999999999999997E-4]
[3,"(AHETF OPML, ex PHED 3) - Mixing/Loading Liquids, liquid products - OPHUE","ü",null,{"$f":"L58/B91","v":0.48501697680673067},{"$f":"M58/B91","v":8.2893810581513974E-2},{"$f":"N58/B91","v":8.2893810581513974E-2},{"$f":"O58/B91","v":6.4154518295799379E-2},{"$f":"P58/B91","v":4.8281235418488189E-4},9.6562470836976383E-5,null,0.22,3.7600000000000001E-2,{"$f":"M58","v":3.7600000000000001E-2},2.9100000000000001E-2,2.1900000000000001E-4,4.3800000000000001E-5]
[4,"(PHED 4) - Mixing/Loading Wettable Powders, powder products - OPHUE","ü",null,{"$f":"L59/B91","v":8.1870865684976142},{"$f":"M59/B91","v":0.36905382689748506},{"$f":"N59/B91","v":0.36905382689748506},{"$f":"O59/B91","v":0.28527816726723154},{"$f":"P59/B91","v":9.5733312268899057E-2},1.9146662453779811E-2,null,3.7136,0.16739999999999999,{"$f":"M59","v":0.16739999999999999},0.12939999999999999,4.3423900000000001E-2,8.6847799999999996E-3]
[5,"(AHETF CCA) - Applicator, Aerial, Fixed-Wing - Liquid - OPHUE",null,"ü",{"$f":"L60/B91","v":4.5856150534454533E-3},{"$f":"M60/B91","v":4.5856150534454533E-3},{"$f":"N60/B91","v":1.7659027201008693E-3},{"$f":"G60","v":1.7659027201008693E-3},{"$f":"P60/B91","v":1.0802650847059001E-5},2.1605301694118003E-6,null,2.0799999999999998E-3,{"$f":"L60","v":2.0799999999999998E-3},8.0099999999999995E-4,null,4.8999999999999997E-6,9.7999999999999993E-7]
[6,"(OCAB) - Applicator, Open Cab Airblast - OPHUE",null,"ü",{"$f":"L61/B91","v":3.9021820406723329},{"$f":"M61/B91","v":3.9021820406723329},{"$f":"N61/B91","v":3.5053499687395537},{"$f":"G61","v":3.5053499687395537},{"$f":"P61/B91","v":1.0383772548907733E-2},2.0767545097815465E-3,null,1.77,{"$f":"L61","v":1.77},1.59,1.48,4.7099999999999998E-3,9.4199999999999991E-4]
[7,"(OCGB) - Applicator, Open Cab Groundboom - OPHUE",null,"ü",{"$f":"L62/B91","v":0.17328333807731378},{"$f":"M62/B91","v":0.17328333807731378},{"$f":"N62/B91","v":3.5494424211765289E-2},{"$f":"G62","v":3.5494424211765289E-2},{"$f":"P62/B91","v":7.4957169142858375E-4},1.4991433828571676E-4,null,7.8600000000000003E-2,{"$f":"L62","v":7.8600000000000003E-2},1.61E-2,1.26E-2,3.4000000000000002E-4,6.7999999999999999E-5]
[8,"(PHED 15) - Applicator, Open Cab Solid Broadcast Spreader - OPHUE",null,"ü",{"$f":"L63/B91","v":2.189851650282389E-2},{"$f":"M63/B91","v":2.189851650282389E-2},{"$f":"N63/B91","v":1.5866669009445639E-2},{"$f":"O63/B91","v":9.2197318045715796E-3},{"$f":"P63/B91","v":2.6455471462185306E-3},{"$f":"I63/5","v":5.2910942924370616E-4},null,9.9330000000000009E-3,{"$f":"L63","v":9.9330000000000009E-3},7.1970000000000003E-3,4.182E-3,1.1999999999999999E-3,{"$f":"P63/5","v":2.3999999999999998E-4}]
[9,"Applicator, Granules by Hand (granular bait) - OPHUE",null,"ü",{"$f":"L64/B91","v":228.77368946924744},{"$f":"M64/B91","v":228.77368946924744},{"$f":"N64/B91","v":157.14550048538072},{"$f":"O64/B91","v":88.802199208068686},{"$f":"P64/B91","v":1.0361726322689244},0.20723452645378487,null,103.77,{"$f":"L64","v":103.77},71.28,40.28,0.47,9.4E-2]
[10,"low pressure handwand for powder products - OPHUE","ü","ü",{"$f":"L65/B91","v":64.22065697445484},null,{"$f":"N65*B91","v":3.9054303056999999},null,{"$f":"P65/B91","v":2.4250848840336534},{"$f":"I65/5","v":0.48501697680673067},null,29.13,null,8.61,null,1.1000000000000001,{"$f":"P65/5","v":0.22000000000000003}]
[11,"Mixer/Loader/Applicator, Backpack Sprayer - General Broadcast/Foliar Applications - Greenhouses (backpack for liquid and granule products) - OPHUE","ü","ü",{"$f":"L66/B91","v":29.101018608403837},null,{"$f":"N66/B91","v":24.691773364706286},null,{"$f":"P66/B91","v":0.30864716705882861},{"$f":"I66/5","v":6.1729433411765719E-2},null,13.2,null,11.2,null,0.14000000000000001,2.8000000000000001E-2]
[12,"(PHED 35) - Mixer/Loader/Applicator, Mechanically-pressurized Handgun Sprayer, Greenhouses, Mushroom houses, General Broadcast/Foliar Applications (high pressure handwand for liquid and granule products) - OPHUE","ü","ü",{"$f":"L67/B91","v":7.8153871944539093},null,{"$f":"N67/B91","v":5.5732859880337049},null,{"$f":"P67/B91","v":0.26455471462185309},{"$f":"I67/5","v":5.2910942924370617E-2},null,3.5449999999999999,null,2.528,null,0.12,{"$f":"P67/5","v":2.4E-2}]
[13,"backpack for powder products m/l - German model","ü",null,50,0.5,0.5,null,0.8,{"$f":"I68/5","v":0.16},null,{"$f":"E68*B91","v":22.6796185},{"$f":"F68*B91","v":0.22679618500000001},{"$f":"G68*B91","v":0.22679618500000001},null,{"$f":"I68*B91","v":0.36287389600000003},{"$f":"P68/5","v":7.2574779200000009E-2}]
[14,"backpack for powder products appl - German Model",null,"ü",16.649999999999999,16.649999999999999,6.1559999999999997,null,0.3,0.06,null,{"$f":"E69*B91","v":7.5523129605000001},{"$f":"F69*B91","v":7.5523129605000001},{"$f":"G69*B91","v":2.7923146297199999},null,{"$f":"I69*B91","v":0.13607771099999999},2.7215542199999998E-2]
[15]
[16]
[17]
[18]
[19]
[20]
[21]
[22]
[23]
[24]
[25]
[26]
[27]
[28]
[29]
[30]
[31]
[32]
[33]
[34]
[35]
["1 lb =",0.45359237000000002,"kg"]

{"sheet":"Version Control","index":6,"n_rows":12,"n_cols":2,"rows_kept":12,"cut":false,"hidden":false,"merged":[[11,1,11,15],[7,1,7,15],[3,1,3,15],[8,1,8,15],[9,1,9,15],[4,1,4,15],[5,1,5,15],[6,1,6,15]]}
["Version control"]
[]
["Difference between Version 1.7 and version 2.2:"]
["1-","Verion 2.3 introduces the calculation of route specific AOEL as Tier-2. It makes MOE calculation and % dermal+inhalation AOEL calculation at tier-2 consistent when route specific dermal NOAEL and/or inhalation NOAEL are used as input.\nAt tier-1 (only using Oral NOAEL), version 2.3 and version 1.7 calculation are identical."]
["2-","In version 2.3, the AOEL is removed from the input sheet. It is not used as a result ofupdate number 1."]
["3-","In version 2.3, calculated route specific inhalation AOEL and dermal AOEL are added in the summary results. They are calculated as\nInhalation AOEL = Inhalation NOAEL / 100 and Dermal AOEL = Dermal NOAEL / 100."]
["4-","In verion 2.3, the uncertainty factor is removed from the input sheet and a default value of 100 is systematically used for both dermal and inhalation exposure."]
["5-","Version 2.3 address a flaw from version 1.7 on the use of dermal NOAEL in the MOE calculation. In version 1.7, when using a route specific dermal NOAEL as Tier-2, the model was adjusting the MOE calculation for dermal absorption when it should not. This is fixed and it is recommended to recalculate scenarios when dermal NOAEL was used in version 1.7. Version 2.2 is more conservative."]
["6-","In version 1.7, results from column G and H were interchanged for some application techniques. This is fixed."]
["7-","In version 2.3, a new sheet is added (Ouput_OPEX_3) to report the dermal exposure and inhalation exposure expressed mg/kg_bw/d"]
["8-","In version 2.3, the link to the German model is removed as it is not valid anymore. The refernce to the paper documentation is added in the reference list."]
["9-","The short manual is updated accordingly to the difference highlighted above."]